In general, while >50% MEK inhibition was reached in vivo at most doses, 80% inhibition in PBMCs required significantly higher doses and appeared to be the practical maximal level obtained in vivo. In mice, a 50%-80% reduction of MEK activity was sufficient to reduce influenza virus titer in the lungs by more than 90%. Across all species approximately 10 μg/ml zapnometinib was appropriate to inhibit 50% of peripheral blood mononuclear cells (PBMC) MEK activity. Doses were sufficient to cause up to 80% MEK inhibition. Regardless of species or formulation, zapnometinib maximum plasma concentration (C max) was reached between 2-4 h after administration with an elimination half-life of 4-5 h in dogs, 8 h in mice or hamsters and 19 h in human subjects. Beagle dogs were administered 300 mg/kg/day, and healthy human volunteers were administered 100, 300, 600 and 900 mg zapnometinib (once daily p. Syrian hamsters received 30 mg/kg (15 mg/kg twice daily) or 60 mg/kg/day once daily. Mice received 25 mg/kg/day zapnometinib (12.5 mg/kg p. Here, we report zapnometinib PK and PD parameters in mice, hamsters, dogs, and healthy human volunteers. While the antiviral efficacy of zapnometinib is well documented, further data on target engagement/pharmacodynamics (PD) and pharmacokinetics (PK) are needed. She married Fred Chase Koch in 1932,” says the bio.ĥ.The mitogen-activated protein kinase (MEK) inhibitor zapnometinib is in development to treat acute viral infections like COVID-19 and influenza. Koch was also an accomplished silversmith. Mary Koch was “known to express her love of the arts through drawing and painting, Mrs. By 1961, the company’s name had been changed to Rock Island Oil & Refining Co., Inc., and the company was later renamed Koch Industries, Inc., in his honor.” In 1940, Fred Koch co-founded the Wood River Oil and Refining Co., Inc., the predecessor of Koch Industries, Inc. “Following the departure of Keith in 1925, the firm became Winkler-Koch Engineering Company. The firm was later renamed Keith-Winkler-Koch Engineering Company,” the bio explains. Keith, at Keith-Winkler Engineering Company. “He moved to Wichita, Kansas, in 1925 and joined MIT classmate, P.C. It was Fred who started the company that would grow into Koch Industries. In 1919, he left Rice to attend the Massachusetts Institute of Technology, where he became one of the first students to obtain a degree in Chemical Engineering Practice.” He joined the Engineering Society and was elected class president his sophomore year. If any of the kids becomes an engineer, I think it will be he,” he said, according to a Koch Industries biography.įred Koch, according to a Foundation bio in his name, “decided to attend Houston’s Rice Institute in 1917. He is a natural athlete and very practical. According to the Fred and Mary Koch foundation, Mary Clementine Robinson “was the daughter of a Kansas City, Missouri, surgeon who also served as a professor at the University of Kansas School of Medicine.” She later became heavily involved in the arts community.įred had high hopes for the younger Koch son. David Koch was born to on May 3, 1940, to Fred and Mary Koch. David Koch Had Three Children With Julia Koch & Described Himself as ‘Devoted as a Choir Boy’ to Herĭavid Koch was born David Hamilton Koch. Julia has done charity work for example, she was co-chair of the Met’s annual Costume Institute Gala.ģ. In 1998, New York Times Magazine described Julia Koch as “a young woman of manners and social ambition from Conway, Ark., much admired in her Upper East Side circle for marrying one of the richest men in America.” At the time she was 34.Īn ex-girlfriend Cindy Farkas Glanzrock told the Observer that Koch liked having women around in his early days but didn’t discuss politics with them. When she worked for Adolfo, Julia actually occasionally dressed Nancy Reagan “in her famous knit suits,” the magazine article reports. Observer describes her as “a former assistant to the fashion designer Adolfo Dominguez, whom he wed in 1996.” According to New York Magazine, Julia was “the attractive blonde daughter of an Arkansas junk dealer” and “he was 50, she was 27” when they married. GettyJulia Margaret Flesher (L) and David Koch attend 2016 Time 100 Gala, Time’s Most Influential People In The World – Cocktails at Jazz At Lincoln Center at the Times Warner Center on Apin New York City.ĭavid Koch was married to wife Julia Flesher Koch.
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